The treatment of substance use disorders is carried out by specialized treatment providers with a trained multidisciplinary team, with or without pharmaceutical support. However, apart from the treatment of the addiction itself, contact of various health services with people who use drugs at any level is a daily routine. People who use psychoactive substances often refer to Emergency Departments, but also clinics of many specialties that deal with co-morbidities. The recent "Medical Manual for Emergencies Related to the Use of Psychoactive Substances" aims, on the one hand, to provide clinical guidelines for the provision of care in various therapeutic conditions, when clinical problems such as toxicosis and withdrawal are faced by the non-specialist clinician, in all tiers of health care in various therapeutic settings, and on the other hand in facilitating the interface between health services and addiction agencies. Particular emphasis is placed on the treatment of withdrawal syndrome in women during the various phases of pregnancy, puerperium and breastfeeding, and the particular requirements of overdose treatment in pregnant women users of psychoactive substances. Speakers will present the clinical guidelines and they will discuss illustrative clinical cases with the audience.